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I am looking for a secure bag or box to lock medicine in for elderly parents until the weekly pill box is filled. Everything that I am finding is too small (will not hold all the bottles one parent has). Im also seeing comments about keys verses combination problems. Any suggestions would be appreciated!

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Pharmacies can pack time of day salad packs of medications for each person. A liquor cabinet that locks or a gun cabinet (not glass) can also work. There are pill minder boxes that ring an alarm at medication time.
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I went to walmart and got a floating lock box out of the boating section. It is large enough to hold all the medication and is bright orange. Which would be hard to overlook if we had to evacuate due to bad weather
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Again, it depends on whom you are locking out. Your parents with dementia, or burglars. Burglars go right to locked boxes and safes. If you are hiding from your parents and less worried about burglars, go with the simple locked box that would be easier for you to reach into so you or a nurse can dispense to them. Remember you have caregivers either now or in the future to worry about. You hope they don't steal, of course. But you do not want to make it tempting. I know with my friends's dad, his nurse (whom they knew and trusted) had license to hold onto the bottles and only a few days' worth was at his apartment. She brought the pills and dispensed them, so that took care of all past worries. He'd been confused and couldn't keep track anymore.
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When Mom lived home my nephew took care of her pill planner. I had him put the pill bottles and the planner on a shelf she couldn't reach or see what was on it. He would give her the pills each morning.
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We also put a padlock on the crisper drawer of the fridge for refrigerator meds. Used gorrilla glue.
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I hide all medication and OTC meds in a cardboard box and put it in my closet. He never goes in my closet and probably wouldn't know how to open it (it has a hidden sliding door). Put all meds up and out of the reach of parents and if they have dementia, they will soon forget about pills...
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I was just thinking of another type of box you can also get at Walmart where you get all of the beauty products. They have some very nice boxes over there that have latches, some of them are clear. Now in the laundry supplies aisle, there's another kind of box with latches, they come in different sizes. At our Walmart, these particular boxes are right around the laundry baskets, but location may vary between stores so keep your eyes peeled for plastic boxes that have the locking lids. The one I'm talking about right now is kind of like a transparent frosty white with blue latches. I just got one for my aromatherapy supplies, they're very handy
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When my one elderly friend was still living, he just used a simple lock box that happens to be made out of some kind of heavy metal. He lived in an apartment complex, so he kept all of his medicine locked up because he thought people were stealing his meds when really he was the one dropping them all over the floor. A simple lockbox is really a good thing. Another nice box is something that used to have small toys. The kind I have for my meds actually has side clips that hold the lid down. Whatever kind of container you choose, make sure to keep it out of sight and in a safe place where no one can find it. Another good idea is to take it a step further and not keep any pills in the medicine cabinet. That way, everyone stays safe and no one gets tempted, especially snoopers
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RuthieRuth has IMO, the best answer. You could also fill out a garment bag with compartments hanging in closet where winter clothes are.
B. A flat underbed plastic container in guest room

C. Upper unused kitchen cabinets on top of fridge, for example

D. The locking filing cabinet is my first choice.

Just make sure they are not watching when you are refilling for the week. The meds need 2 b @ controlled temps, so...

There's also a portable filing plastic box with handle that locks with padlock - Walmart.

M88
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Practical: old metal file cabinet with a lock on the top. If needed get a welder to attach a padlock to the side and a TSA lock should suffice.
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wildfire: Some pharmacies are now offering an RX bottle with a clock on top...that is one way to know when the elder has gotten into it. Else you can hid the med bottles somewhere in the home.
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How secure do you need this, and what types of worries do you have regarding these pills? Do you need your relatives to have access to it? And whom are you locking out? Sometimes you can simply find a cabinet in the home, and put a lock on it. That will not keep out burglars if they are looking for drugs and know where they are, but it'll discourage a newly-hired home care person that you may not trust yet. That way you have a larger space. Another option if you are worried about burglars and serious thieves is a diversion safe. This is actually safer than a real safe since burglars go to the real safes first. This you could place in a location inaccessible to your parents if you were worried that they may become confused should they find it. There are a variety of incredibly creative ways to hide things that won't cost you a penny, and no one will ever think to look there. (One problem though, you might not, either.) Put :diversion safe" in your favorite search engine to get ideas. You can buy one, or make your own.
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Phillips lifeline has a great dispenser but its pricy. You can put up to 10 days of meds in it. You setbup the time for it to dispense. A voice comes on to tell the patient it is time for meds. The patent hiys the button and the pills come out in a plastic dispenser. It will announce a couple of times if meds are not taken you will get a call. It locks so they can't fool with the meds.
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Are you the only one unlocking the box and dispensing the medications? If you are filling weekly pill containers the bottles could be kept with you off site. Where I live there is also an option to have pills in blister packs delivered weekly from the pharmacy.
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Ideally you get a box securely attached to or built into the wall, with keys. Any locksmith can help you with the right size box. Only you will have the key; combinations can be orally shared or even forgotten.
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